LMTM – International Associated "Laboratory on Molecules from Traditional Medicine”

"LMTM" laboratory is the second "International Associated Laboratory" (LIA) put in place by the CNRS with a Hong Kong partner. It was officially established on the 1st of January 2009 and came up as the result of a nine years old scientific co-operation between two research labs located at the Chinese University of Hong Kong (CUHK) and the “Ecole Nationale Superieure de Chimie de Paris” (ENSCP) which is associated with the National Center for Scientific Research (CNRS). The aim of the researches conducted by this joint laboratory is to develop effective and safe drugs based on products used in traditional Chinese medicine for treating infections caused by Staphylococcus aureus.


The “LMTM” joint lab combines for a period of four years a CNRS and ENSCP joint research unit (UMR 7573), entitled "Laboratory of selective organic synthesis and natural products”, headed by Dr. Virginia Vidal, with the Institute of Chinese Medicine (ICM) of CUHK headed by Prof. Ping Chung Leung and Prof. K. P. Fung. Dr. Claude Jolovalt is specifically responsible for the scientific expertise of the LIA. These people submits research programs, budgets and financial as well Scientifics reports to a steering committee. The latter is composed of representatives of the three institutions.

In order to cope with the resistance of bacteria to antibiotics, new chemical compounds are needed. Gathering their respective expertise, the teams are working to establish a scientific basis for a clinical use of traditional Chinese medicine and identify compounds that can potentially lead to the development of effective and safe drugs for the treatment of multi drug-resistant Staphylococcus aureus.

The Institute of Chinese Medicine (ICM) of CUHK has a strong experience in research on traditional Chinese medicine, especially in the biological analysis of herbs, isolation, identification and modification of active compounds from these herbs.

The biochemical laboratory of the CNRS-ENSCP (UMR 7573) in France is specialized in studying the mechanisms of drug resistance in bacteria such as Staphylococcus aureus and has developed cellular and enzymatic analysis, focused on various mechanisms of drug resistance and allowing a broad screening of compounds having an effect against resistant bacteria or having an inhibitory effect on resistance mechanisms.

The LIA is also participating with an Indian partner to a cooperative research project (TRADICHEM) which is supported by the program "Bio-Asia" of the French Ministry for Foreign and European Affairs. This project aims to identify molecules issued from traditional Chinese and Indian medicines, to fight against human pathogens and cancer cells. The Indian team belongs to the Jammu Institute of Ayurveda and Research.

Contact :
Dr Virginie Vidal
Laboratoire de synthèse sélective organique et produits naturels
Laboratoire de Biochimie – UMR 7573 CNRS-ENSCP
11 rue Pierre et Marie Curie
75231 Paris cedex 05
Tél : 01 44 27 67 42
Email : virginie-vidal@enscp.fr

publié le 07/01/2011

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